Thermo Fisher Scientific CD101 Recombinant Rabbit Monoclonal Antibody (5D6V4)

Applications

Product Specifications

Product Specific Information

Immunogen Sequence:
QREVTVQKGP LFRAEGYPVS IGCNVTGHQG PSEQHFQWSV YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ GNSVLLHISK LQMKDAGEYE CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT MSSQTLGKEE GEPLALTCEA SKATAQHTHL SVTWYLTQDG GGSQATEIIS LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ SSDQGQLFCE ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL QVSKLGPKAF SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD SHVHLRKPAA

Target Information

CD101, also known as V7 antigen, is a member of the immunoglobulin superfamily. It forms a disulfide-linked homodimer of unknown function. CD101 is expressed on monocytes, granulocytes, and dendritic cells (Langerhans-like cells expressing HLA-DR, CD1a, CD1c). Expression on T lymphocytes is important for cell activation. CD101⁺ CD28⁺ cells respond strongly to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can enhance proliferation, suggesting an activating role.

The monoclonal antibody BB27 has been shown to inhibit T cell reactivity in allogeneic and antigen-specific mixed DC–T cell cultures. Mouse CD101 is expressed on a subpopulation of regulatory T cells (CD4⁺, CD25⁺, Foxp3⁺) with high suppressor activity. In human PBMCs, CD101 expression is observed on approximately 30% of Foxp3⁺ cells, although enhanced suppressor activity has not been confirmed in humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.