Thermo Fisher Scientific E-cadherin Polyclonal Antibody
Rabbit polyclonal antibody targeting human E-cadherin (CDH1). Validated for Western blot and flow cytometry. High purity (1.6 mg/mL) liquid form with PBS buffer. Suitable for cancer research and cell adhesion studies.
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- PA511549
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 833–862 of the C-terminal region of human E-Cadherin (CDH1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.6 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2275927 |
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a glycoprotein involved in calcium-dependent cell–cell adhesion and consists of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in the CDH1 gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function contributes to cancer progression by promoting proliferation, invasion, and metastasis. The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization.
E-cadherin plays a central role in maintaining tissue architecture and integrity, and reduction or loss of expression correlates with increased invasiveness in carcinomas. The human E-cadherin gene (CDH1) is located on chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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