Thermo Fisher Scientific L3MBTL1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human L3MBTL1(Accession Q9Y468), corresponding to amino acid residues D452-S502. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:L3MBTL1,uniProtId:Q9Y468-5,ncbiNodeId:9606,antigenRange:452-502,antigenLength:840,antigenImageFileName:PA5-115488_L3MBTL1_Q9Y468-5_Rabbit.svg,antigenImageFileNamePDP:PA5-115488_L3MBTL1_Q9Y468-5_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2900124

Product Specific Information

Antibody detects endogenous levels of total L3MBTL1.

Target Information

L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.