Thermo Fisher Scientific ATP2C1 Monoclonal Antibody (4G12)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15592 targets ATP2C1 in indirect ELISA, IHC, and WB applications, showing reactivity with human and non-human primate samples.
The immunogen is a purified recombinant fragment of ATP2C1 expressed in E. coli.
MA5-15592 detects ATP2C1, which has a predicted molecular weight of approximately 100 kDa.

Target Information

ATP2C1, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA1), belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes ATP hydrolysis coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin.
Unlike the related ATP2C2 protein, ATP2C1 is ubiquitously expressed and exhibits a lower maximal turnover rate for overall Ca²⁺-ATPase reaction and a higher apparent affinity for cytosolic Ca²⁺ activation of phosphorylation.
Recent evidence suggests ATP2C1 regulates insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.