Thermo Fisher Scientific ITGA2/CD49B/Integrin alpha-2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ITGA2/CD49B (Integrin alpha-2). Validated for WB and IP applications. High purity via antigen affinity chromatography. Supplied as liquid at 1 mg/mL, ideal for research use in cell adhesion and signaling studies.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 to 75 of human Integrin alpha-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with a molecular weight of approximately 150 kD and complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (Integrin alpha 2 beta 1, or GPIa/IIa) complex.
VLA-2 acts as an extracellular receptor for laminin, collagen, and fibronectin, triggering intracellular signaling upon ligand binding.
It plays roles in VEGF-induced angiogenesis, cell adhesion, and lymphocyte activation.
CD49b is expressed in NK cells, NK-T cells, monocytes, platelets, epithelial cells, and subsets of T and B cells, including CD4+ Tr1 regulatory cells co-expressing LAG-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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