Thermo Fisher Scientific T4S20 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human T4S20. Recombinant protein control fragment (Product #RP-104287). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:T4S20,uniProtId:Q53R12-1,ncbiNodeId:9606,antigenRange:136-191,antigenLength:229,antigenImageFileName:PA5-62495_T4S20_Q53R12-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62495_T4S20_Q53R12-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648173

Product Specific Information

Immunogen sequence: IHPESFNLQW FFNDSCAPPT GFNKPTSNDT MASGWRASSF HFDSEENKHR LIHFSV

Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 52%.

Target Information

Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called regulated alternative translocation (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.