Thermo Fisher Scientific T4S20 Polyclonal Antibody
Human T4S20 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(Paraffin)에서 1:50~1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human T4S20. Recombinant protein control fragment (Product #RP-104287). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648173 |
Product Specific Information
Immunogen sequence:
IHPESFNLQW FFNDSCAPPT GFNKPTSNDT MASGWRASSF HFDSEENKHR LIHFSV
Highest antigen sequence identity to the following orthologs:
- Mouse: 52%
- Rat: 52%
Target Information
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293).
In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293).
Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20. This mechanism, called regulated alternative translocation (RAT), regulates the function of the transmembrane protein (PubMed:27499293).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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