Thermo Fisher Scientific Epoc-1 Monoclonal Antibody (34H8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

ELISA (ELISA)

0.05-1 µg/mL

-

Product Specifications

Host/Isotype

Mouse / IgG1, lambda

Class

Monoclonal

Type

Antibody

Clone

34H8

Immunogen

Recombinant Mouse Epoc-1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.

POU2F3 (POU Class 2 Homeobox 3) encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for POU2F3. Epoc-1 binds to the octamer motif (5-ATTTGCAT-3). It is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. Epoc-1 is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer.

Target Information

This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.