Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (PAb122)

Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (PAb122)

Applications

• ELISA (ELISA): Assay-dependent
• Peptide Array (Array): Assay-dependent

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or pyrimidine nucleotide starvation. Upon activation, p53 induces transcription of genes such as p21waf1, leading to G1 or G2/M arrest.

Structurally, p53 includes:

• N-terminal transactivation domain
• Central DNA-binding domain
• Oligomerisation domain
• C-terminal regulatory domain

Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with human tumor formation. p53 plays a key role in inhibiting proliferation of damaged cells and functions as an anticancer agent. It is also linked to aging, oxidative stress, and cognitive deficits related to learning and memory.

In normal cells, p53 levels are low, but in transformed cell lines, it is highly expressed and contributes to malignancy. Mutations in TP53 often lead to loss of DNA binding and tumor suppressor function. Germline mutations are also associated with cancer-prone syndromes such as Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.