Thermo Fisher Scientific COL11A1 Polyclonal Antibody

Thermo Fisher Scientific COL11A1 Polyclonal Antibody

Applications and Tested Dilution

• Application: Immunocytochemistry (ICC/IF)
• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
DCDSSAPKAAQ AQEPQIDEYA PEDIIEYDYE YGEAEYKEAE SVTEGPTVTE ETIAQTEANI VDDFQEYNYG

Highest antigen sequence identity to the following orthologs:

• Mouse: 85%
• Rat: 86%

Target Information

Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. It plays an important role in fibrillogenesis by controlling the lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: α1(XI), α2(XI), and α3(XI). The α3(XI) chain is a post-translational modification of α1(II), and α1(V) can also substitute for α3(XI).

Collagen Type XI has three named isoforms (A, B, C) and additional isoforms generated by alternative usage of exon IIA or IIB. Transcripts containing exon IIA or IIB are found in cartilage, with exon IIB preferentially utilized in tendon. It contains a single collagen-binding TSP N-terminal (TSPN) domain and is expressed in cartilage, placenta, and certain tumor or virally transformed cell lines. Isoform expression can be tissue-specific.

Defects in the COL11A gene cause Stickler syndrome type 2 (STL2), characterized by irregularly thickened fiber bundles throughout the vitreous cavity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음 – OCR 텍스트 통합 완료)