Thermo Fisher Scientific RNF169 Polyclonal Antibody
Human RNF169 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 용액 형태로 제공됩니다. DNA 손상 복구 연구용으로 활용 가능합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human RNF169 (Product # RP-106847) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664117 |
Product Specific Information
Immunogen sequence:
KAKVTTMTPAS NPIIGVLLST QNNRCVSAPD LTIEKRLPFS SLSSLASLHK PERSVSPESN DSISEELNHF KPIVCSPCTP PKRLPDGRVL SPLIIKSTPR NLN
Highest antigen sequence identity to the following orthologs:
- Mouse: 91%
- Rat: 91%
Target Information
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. It is recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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