Thermo Fisher Scientific AUH Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
KLAINQGMEV DLVTGLAIEE ACYAQTIPTK DRLEGLLAFK EKRPPRYKGE

Target Information

The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3′ UTR of rapidly decaying mRNA such as c-fos, c-myc, and granulocyte/macrophage colony-stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation.

AUH is homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has intrinsic hydratase enzymatic activity. It functions as a bifunctional chimera between RNA-binding and metabolic enzyme activity. A possible mitochondrial localization has been demonstrated for the mouse homolog, which shares 92% identity with the human protein. AUH may act as a mitochondrial AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb and translated as a 40-kDa precursor protein, subsequently processed to a 32-kDa mature form.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.