Thermo Fisher Scientific GSTA2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive control: HepG2
• Predicted reactivity: Pig (82%), Rhesus Monkey (92%)
• Store product as a concentrated solution
• Centrifuge briefly prior to opening the vial

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes detoxify electrophilic compounds such as carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products by conjugation with glutathione. The genes encoding these enzymes are highly polymorphic, influencing susceptibility to toxins and drug metabolism.

Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the alpha class, located on chromosome 6, and is abundantly expressed in the liver.
The alpha class enzymes metabolize bilirubin and certain anti-cancer drugs and exhibit glutathione peroxidase activity, protecting cells from reactive oxygen species and peroxidation products.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.