Thermo Fisher Scientific TLR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

TLR1 protein is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate cytokine production necessary for effective immune responses.

The mammalian TLR family consists of transmembrane proteins characterized by multiple leucine-rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. TLRs may represent an important component of innate immunity in humans. In mice, TLR1 interacts with TLR2, and co-expression enhances NF-κB activation in response to synthetic lipopeptides. They recognize lipid configurations of native mycobacterial lipoproteins as well as several tri-acylated lipopeptides. Alternative splicing and polyadenylation may lead to different transcript lengths for the TLR1 gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)