Thermo Fisher Scientific CDH11 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: U-87MG, A-549, HT-29
• Cellular Location: Cell membrane, Single-pass type I membrane protein

Immunogen Sequence:
ERAQYTLMAQ AVDRDTNRPL EPPSEFIVKV QDINDNPPEF LHETYHANVP ERSNVGTSVI QVTASDADDP TYGNSAKLVY SILEGQPYFS VEAQTGIIRT ALPNMDREAK EEYHVVIQAK DMGGHMGGLS GTTKVTITLT DVNDNPPKFP QSVYQMSVSE AAVPGEEVGR VKAKDPDIGE NGLVTYNIVD GDGMESFEIT TDYETQEGVI KLKKPVDFET KRAYSLKVEA ANVHIDPKFI SNGPFKDTVT VKISVEDADE PPMFLAPSYI HEVQENAAAG T

Target Information

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion.
All cadherins are single-pass transmembrane proteins with a variable number of extracellular cadherin (EC) domains.
Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain.

Type II cadherins include human cadherin-5, -6, -8, -11, and -12, defined by the lack of a HAV cell adhesion recognition sequence.
Cadherin-11 (OB-Cadherin) is a marker of mesenchymal cells and is strongly expressed in brain, spinal cord, bone marrow, and bone cells.
It plays a role in bone development and maintenance.
Cadherin-11 is also associated with invasive breast cancer cell lines, suggesting its potential as a marker for aggressive tumor subsets.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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