Thermo Fisher Scientific LIN7C Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human LIN7C. Recombinant protein control fragment (Product #RP-99522). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LIN7C,uniProtId:Q9NUP9-1,ncbiNodeId:9606,antigenRange:48-72,antigenLength:197,antigenImageFileName:PA5-62320_LIN7C_Q9NUP9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62320_LIN7C_Q9NUP9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643381

Product Specific Information

Immunogen sequence: NAVREVYEHV YETVDISSSP EVRAN

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

Protein assembly at the post synaptic density (PSD) of neuronal synapses is mediated in part by protein interactions with PDZ (PSD-95/discs large/zona occludens-1) motifs. The Mammalian LIN-7 (MALS) proteins are a family of small synaptic proteins that are the mammalian homologs of LIN-7, a C. elegans protein essential for vulval development. MALS proteins are also known as Veli (Vertebrate Lin-7) proteins. MALS-3 mRNA is most abundant in kidney, followed by brain, liver, thymus and heart. MALS-3 is undetectable in spleen. In cultured cortical neurons, MALS proteins are clustered together with PSD-95 and NMDA-type glutamate receptors. MALS proteins are suggested to have roles in regulating the recruitment of neurotransmitter receptors to the PSD and in the assembly of proteins involved in synaptic vesicle exocytosis and synaptic junctions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.