Thermo Fisher Scientific FADD Monoclonal Antibody (3C2)
FADD 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체. Western blot 및 ELISA 검증 완료. 세포 사멸 신호 전달 연구에 적합. PBS 용액 내 액상 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C2 |
| Immunogen | FADD (AAH00334, 109 a.a. – approximately 208 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GKDWRRLARQ LKVSDTKIDS IEDRYPRNLT ERVRESLRIW KNTEKENATV AHLVGALRSC QMNLVADLVQ EVQQARDLQN RSGAMSPMSW NSDASTSEAS
Target Information
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates apoptotic signals. Through its C-terminal death domain, it can be recruited by TNFRSF6/Fas-receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, participating in death signaling initiated by these receptors. Interaction with receptors unmasks the N-terminal effector domain, allowing recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice suggest its importance in early T cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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