Thermo Fisher Scientific FADD Monoclonal Antibody (1G6)
FADD 단백질을 인식하는 Mouse IgG1 monoclonal antibody (clone 1G6). Western blot과 ELISA에 최적화되어 있으며, 인간 시료에 반응. PBS buffer, no preservative, -20°C 보관. 세포 사멸 신호 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G6 |
| Immunogen | FADD (AAH00334, 109–208 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GKDWRRLARQ LKVSDTKIDS IEDRYPRNLT ERVRESLRIW KNTEKENATV AHLVGALRSC QMNLVADLVQ EVQQARDLQN RSGAMSPMSW NSDASTSEAS
Target Information
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, participating in death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain, allowing recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice suggest its importance in early T cell development.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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