ELK Biotechnology CD3-δ rabbit pAb
CD3-δ rabbit pAb는 인간, 랫트, 마우스 시료에 반응하는 폴리클로날 항체로, T세포 수용체 복합체 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 세포막 단백질 CD3D를 인식합니다. -20°C에서 1년간 안정적으로 보관됩니다.
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ELK Biotechnology CD3-δ rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CD3-δ rabbit pAb |
| Alternative Names | CD3D; T3D; T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; CD3d |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 IHC-p: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human CD3D (AA range: 41–90) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 18 kD |
| Gene ID (Human) | 915 |
| Human Swiss-Prot No. | P04234 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells.
Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts have yet to be defined.
[provided by RefSeq, Feb 2009]
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