ELK Biotechnology MDA-7 rabbit pAb
MDA-7(IL-24) 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 랫드, 마우스 반응성. 암세포에서 선택적 아폽토시스 유도 연구에 적합. -20°C에서 1년 보관.
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ELK Biotechnology MDA-7 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MDA-7 rabbit pAb |
| Alternative Names | IL24; MDA7; ST16; Interleukin-24; IL-24; Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 IHC-p: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from the internal region of human IL24 (AA range: 131–180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 24 kDa |
| Gene ID (Human) | 11009 |
| Human Swiss-Prot No. | Q13007 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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