ELK Biotechnology LXRα rabbit pAb
LXRα rabbit pAb는 인간, 마우스, 랫드, 햄스터에 반응하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며, 핵 및 세포질 내 단백질 검출에 적합합니다. NR1H3 유래 펩타이드로부터 제작되었으며, -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology LXRα rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | LXRα rabbit pAb |
| Alternative Names | NR1H3; LXRA; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human NR1H3 (AA range: 151–200) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 10062 |
| Human Swiss-Prot No. | Q13133 |
| Cellular Localization | Nucleus, Cytoplasm |
| Species Reactivity | Human; Mouse; Rat; Golden hamster |
Background
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney, and intestine. It forms a heterodimer with retinoid X receptor (RXR) and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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