ELK Biotechnology TF rabbit pAb
인간, 쥐, 랫트 시료에 반응하는 TF rabbit polyclonal antibody. Western Blot, IHC, IF, ELISA에 적합하며, 응고인자 III 검출에 사용. 합성 펩타이드 항원으로 제작되어 높은 특이성과 재현성을 제공. -20°C 보관 시 1년 안정.
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제품명
TF rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | F3; Tissue factor; TF; Coagulation factor III; Thromboplastin; CD142 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 IHC-p: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from the internal region of human F3 (AA range: 131–180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 33 kD |
| Gene ID (Human) | 2152 |
| Human Swiss-Prot No. | P13726 |
| Cellular Localization | Isoform 1: Membrane; Single-pass type I membrane protein Isoform 2: Secreted |
| Species Reactivity | Human; Rat; Mouse |
배경 (Background)
This gene encodes coagulation factor III, a cell surface glycoprotein that enables cells to initiate blood coagulation cascades. It functions as the high-affinity receptor for coagulation factor VII. The resulting complex provides a catalytic event responsible for initiating coagulation protease cascades through specific limited proteolysis. Unlike other cofactors that circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces.
There are three distinct domains: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants. (Provided by RefSeq, May 2010)
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