ELK Biotechnology NF90 rabbit pAb
NF90 rabbit pAb는 인간 NF90 단백질을 인식하는 고품질 polyclonal 항체로, WB 및 ELISA에 적합합니다. 세포 내 NF90의 핵 및 세포질 위치 분석에 활용되며, mRNA 안정화 및 전사 조절 연구에 유용합니다.
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제품명
NF90 rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ILF3; DRBF; MPHOSPH4; NF90; Interleukin enhancer-binding factor 3; Double-stranded RNA-binding protein 76; DRBP76; M-phase phosphoprotein 4; MPP4; Nuclear factor associated with dsRNA; NFAR; Nuclear factor of activated T-cells 90 kDa; NF-AT-90; Translational control protein 80; TCP80 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000; ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NF90. AA range: 302–351 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 95 kDa |
| GeneID (Human) | 3609 |
| Human Swiss-Prot No | Q12906 |
| Cellular Localization | Nucleus, nucleolus, cytoplasm. Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. NF90 (ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex affects the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 retards cell growth, possibly by inhibition of mRNA stabilization. The NF110 isoform, predominantly nuclear, has minor effects on cell growth reduction. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [Provided by RefSeq, Dec 2014]
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