Thermo Fisher Scientific MBP Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. MBP-related transcripts are also present in bone marrow and the immune system. These mRNAs arise from the long MBP gene (also called Golli-MBP), which contains three additional exons located upstream of the classic MBP exons.
Alternative splicing from the Golli and MBP transcription start sites produces two sets of MBP-related transcripts and gene products. The Golli mRNAs encode hybrid proteins with N-terminal Golli amino acid sequences linked to MBP sequences, while the second family contains only MBP exons and produces the well-characterized myelin basic proteins.
This complex gene structure is conserved among species, suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for gene function and regulation.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.