Thermo Fisher Scientific CHEK2 Monoclonal Antibody (OTI2F4), TrueMAB
Human CHEK2 단백질을 인식하는 Mouse IgG1 단클론 항체로, ELISA 및 Luminex 분석에 적합. TrueMAB 형식으로 고순도 정제되어 있으며, 안정적인 액상 형태로 제공. DNA 손상 체크포인트 연구 및 암 관련 단백질 분석에 활용 가능.
- 카탈로그번호
- TA600006
- 판매단위
- pk
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Applications
ELISA (ELISA)
- Tested Dilution: 1:100–1:1,000
Luminex (LUM)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F4 |
| Immunogen | Full length human recombinant protein of human CHEK2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. Mutations in CHK2 have been linked to various cancers. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control, including tumor suppressor proteins. It can phosphorylate BRCA1, aiding in cell survival after DNA damage. CHK2 is considered a tumor suppressor protein, with mutations associated with Li-Fraumeni syndrome and predispositions to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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