Thermo Fisher Scientific RAB21 Monoclonal Antibody (OTI4A6)
RAB21 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI4A6). Western blot, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A6 |
| Immunogen | Full length human recombinant protein of RAB21 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723543 |
Target Information
RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting.
In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles.
RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes.
The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the alpha-tail of endocytosed integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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