Thermo Fisher Scientific KDM5B Polyclonal Antibody
인간 KDM5B 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS(glycerol 40%) 용액 형태로 제공됩니다. KDM5B의 히스톤 탈메틸화 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KDM5B (Product #RP-106489) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856785 |
Product Specific Information
Immunogen sequence:
PARRAKRMRA EAMNIKIEPE ETTEARTHNL RRRMGCPTPK CENEKEMKSS IKQEPIERKD YIVENEKEKP KSRSKKATNA VDLYVCLLCG SGNDEDRL
Target Information
KDM5B is a histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in the histone code. It does not demethylate histone H3 Lys-9 or H3 Lys-27. KDM5B demethylates trimethylated, dimethylated, and monomethylated H3 Lys-4. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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