Thermo Fisher Scientific TIMP4 Polyclonal Antibody
TIMP4 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western Blot과 Immunocytochemistry에 적합합니다. 인간 반응성, 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 안정적이며 장기 보관 시 -20°C에서 유지 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 19–224 of Human TIMP4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.46 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547702 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HepG2, HCT116
- Predicted reactivity: Mouse (91%), Rat (92%), Dog (95%), Rabbit (95%), Rhesus Monkey (99%), Bovine (91%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Tissue inhibitor of metalloproteinase 4 (TIMP4) is encoded by the gene TIMP4 located on chromosome 3. It belongs to the family of TIMP genes and inhibits the activity of matrix metalloproteinases (MMPs), which degrade extracellular matrix components. TIMP4 irreversibly binds to MMPs and inactivates them with zinc as a cofactor. The netrin domain of TIMP4 is involved in platelet recruitment and aggregation. Other biological functions include response to cytokine and peptide hormone stimuli, and involvement in ovulation cycle and CNS development.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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