Thermo Fisher Scientific Cyclophilin A Polyclonal Antibody
Cyclophilin A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능하며 다양한 종에 반응. 고순도 항원 친화 크로마토그래피 정제, 안정적 액상 형태로 장기 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:20,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 93–165 of Human Cyclophilin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545565 |
Product Specific Information
- Recommended positive controls: HepG2, Raji WCE, Raji C+M, Raji NE, mouse brain
- Predicted reactivity: Mouse (100%), Rat (100%), Cat (100%), Pig (100%), Sheep (100%), Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Immunophilins are soluble cytosolic receptors that bind immunosuppressant agents cyclosporin A (CsA) or FK506. Proteins binding FK506 are FK506 Binding Proteins (FKBPs), while those binding CsA are cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium and calmodulin-dependent protein phosphatase involved in T-cell activation, explaining the immunosuppressive mechanism of CsA and FK506.
Immunophilins act as peptidyl prolyl cis-trans-isomerases (PPIase), accelerating protein folding in vivo and in vitro. Within the cyclophilin family, CyPA (also known as CyP-18) is the most abundant and ubiquitous member, found in all vertebrate tissues including T-cells.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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