Thermo Fisher Scientific NMT2 Monoclonal Antibody (OTI2A5)
NMT2 단백질을 인식하는 Mouse monoclonal 항체로 Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, PBS/BSA/glycerol buffer에 보관. 연구용으로 단백질 분해 및 유비퀴틴-프로테아좀 경로 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A5 |
| Immunogen | Full length human recombinant protein of NMT2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.79 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723404 |
Target Information
Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cytosol and nucleus, while others are degraded via the vacuolar pathway (endosomes, lysosomes, ER).
The 26S proteasome is an ATP-dependent, multisubunit complex (~2.5 MDa) composed of a 20S core and 19S regulatory subunits that recognize ubiquitinated proteins, unfold them, and translocate them for degradation.
Defects in this pathway are linked to diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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