Thermo Fisher Scientific KCNN2 Polyclonal Antibody
KCNN2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC 등 다양한 응용에 적합. C-말단 합성 펩타이드로 면역생성. 단백질 A로 정제된 액상 형태로 제공되며, -20°C 보관 권장.
- 카탈로그번호
- PA541012
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | - |
| Immunohistochemistry (IHC) | 1:300–1:500 | - |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human KCNN2 (aa 443–492) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2605450 |
Product Specific Information
Peptide sequence:
IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL NDQANTLVDL AKTQNIMYDM
Sequence homology:
Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 100%; Zebrafish: 93%
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and influence neuronal firing patterns. Each AHP component is kinetically distinct and mediated by different calcium-activated potassium channels.
The KCNN2-encoded protein is activated before membrane hyperpolarization and contributes to the slow component of synaptic AHP, regulating neuronal excitability. It forms a voltage-independent calcium-activated channel with three calmodulin-binding subunits.
This gene belongs to the KCNN family of potassium channel genes, and two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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