Thermo Fisher Scientific SMAD1 Recombinant Rabbit Monoclonal Antibody (SD2090)
SMAD1 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot, IHC, ICC/IF, Flow Cytometry에 적합. HEK293 세포에서 발현된 IgG 형식의 항체로, Protein A로 정제됨. 세포 성장 및 BMP 신호전달 연구에 활용 가능.
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- MA541184
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD2090 |
| Immunogen | Recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898938 |
Target Information
The SMAD1 gene encodes a member of the SMAD family, which are signal transducers and transcriptional modulators similar to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins mediate multiple signaling pathways, particularly those of bone morphogenetic proteins (BMPs), which regulate cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, SMAD1 is phosphorylated and forms a complex with SMAD4, enabling transcriptional regulation. It is also targeted by SMAD-specific E3 ubiquitin ligases such as SMURF1 and SMURF2, leading to ubiquitination and proteasomal degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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