Thermo Fisher Scientific Phospho-p38 MAPK (Thr180) Recombinant Rabbit Monoclonal Antibody (23GB4920)
Phospho-p38 MAPK (Thr180) 인산화 형태를 특이적으로 인식하는 재조합 단일클론 항체. Western blot 및 Flow cytometry에 적합. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 안정한 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific Phospho-p38 MAPK (Thr180) Recombinant Rabbit Monoclonal Antibody (Clone 23GB4920)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB4920 |
| Immunogen | A synthesized peptide derived from human Phospho-p38 (Thr180) (173–187AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motif. There are four isoforms of p38 MAPK, differing in tissue expression and affinity for upstream activators and downstream effectors. Upon exposure to tumor necrosis factor, interleukin-1, heat shock, or other stimuli, MAPK kinase-3 becomes phosphorylated and activates MAPK kinase-3/6, which phosphorylate Thr180 and Tyr182 residues in p38 MAPK. Phospho-p38 MAPK activates transcription factors such as ATF-2, CHOP-1, and MEF-2 through phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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