Thermo Fisher Scientific CDKL2 Monoclonal Antibody (OTI12C2), TrueMAB
CDKL2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 IHC(Paraffin)에서 사용 가능. 인간 반응성, 액상 형태, 1 mg/mL 농도. 연구용으로 신호전달 경로 분석에 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12C2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 291–493 of human CDKL2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK1 and ERK2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites within a characteristic Thr-Glu-Tyr motif.
The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group and closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain, and lung. It contains the conserved MAP kinase dual phosphorylation motif (Thr-Asp-Tyr) and is activated by EGF treatment. Unlike other MAP kinases, EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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