Thermo Fisher Scientific IFN gamma Polyclonal Antibody
인간 IFN gamma를 인식하는 Rabbit Polyclonal 항체로 다양한 응용(WB, IHC, ICC, ELISA)에 적합합니다. KLH 결합 합성 펩타이드(aa 81-166)로 면역화되었으며, Protein A로 정제된 1 mg/mL 액상 형태입니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human IFN Gamma (amino acids 81–166) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, and other cytokines. It is a dimeric glycoprotein composed of two 146 amino acid subunits, functioning as a homodimer of approximately 45 kDa.
On SDS-PAGE, IFN gamma appears as 25, 20, and minor 15.5 kDa bands due to differential glycosylation. Its biological activity is species-specific; human IFN gamma does not cross-react with mouse IFN gamma.
Functions include:
- Antiviral and tumor antiproliferative activity
- Induction of class I and II MHC
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
Activation occurs via IFN gamma receptor I and II, leading to JAK-STAT pathway activation. Human IFN gamma shares ~40% sequence homology with mouse IFN gamma. Expression is upregulated by IL2, FGF basic, and EGF, and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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