Thermo Fisher Scientific Integrin beta 1 Polyclonal Antibody
Integrin beta 1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합합니다. Human, Mouse 등 여러 종에 반응하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1 µg/test |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Sheep, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Integrin beta 1 (amino acids 25–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cell types, including all leukocytes. It forms non-covalently linked heterodimers with multiple alpha chains (α1–α6), determining the binding properties of beta1 (VLA) integrins. ITGB1 functions as a cell adhesion molecule on platelets and mediates interactions with extracellular matrix proteins.
Decreased ITGB1 expression is associated with multidrug resistance in tumor cells. It is up-regulated during leukocyte migration and plays a critical role in immune cell trafficking and inflammation processes such as inflammatory bowel disease. ITGB1 also mediates fibronectin and collagen-induced cytokine secretion in airway smooth muscle cells. Two major isoforms, beta1A and beta1D, differ by 13 amino acids and exhibit tissue-specific expression patterns—beta1A in most tissues and beta1D in cardiac and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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