Thermo Fisher Scientific ITGB1 Monoclonal Antibody (HM beta 1-1)
ITGB1 단백질을 표적하는 HM beta 1-1 클론의 단클론 항체로, 마우스 및 랫트 시료에 반응합니다. Flow Cytometry, IP, Functional Assay에 적합하며, 저엔도톡신·무보존제 제형으로 제공됩니다. 세포 부착 및 면역세포 이동 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Flow Cytometry (Flow) | 1:50–1:100 | |
| Immunoprecipitation (IP) | Assay-dependent | |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Armenian hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HM beta 1-1 |
| Immunogen | Purified mouse VLA-4 antigen (Integrin beta 1, CD29; UniProt ID: P09055-1; amino acids 1–798) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538199 |
Additional Formats Available:
Product Specific Information
- Low-endotoxin, preservative-free formulation (Endotoxin <0.01 EU/mg).
- For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Target Information
ITGB1 (Integrin Subunit Beta 1, CD29) is a 110 kDa cell surface glycoprotein expressed in various cell types including all leukocytes. It forms heterodimers with multiple alpha chains (α1–α6), determining binding properties of β1 integrins (VLA family).
ITGB1 participates in cell adhesion, platelet aggregation, and extracellular matrix binding. Its expression correlates with tumor multidrug resistance and immune cell trafficking. Upregulation occurs during leukocyte migration and inflammatory responses.
Two major isoforms, β1A and β1D, show tissue-specific expression: β1A in most tissues and β1D in cardiac and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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