Thermo Fisher Scientific Caspase 1 Polyclonal Antibody
Caspase-1 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. Western blot, IHC, ICC/IF에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 용액 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–197 of Human Caspase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544863 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HepG2, HCT116, THP-1 conditioned medium (500 ng/mL LPS treatment for 4 hr and 1 mM ATP treatment for 1.5 hr)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, inflammatory caspases are generally not involved in cell death but play roles in immune responses to microbial pathogens. Members such as caspase-1, -4, -5, and -12 activate proinflammatory cytokines including IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme and later found to be a mammalian homolog of the C. elegans cell death gene ced-3, capable of inducing apoptosis in fibroblasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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