Thermo Fisher Scientific Caspase 1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, HepG2, HCT116, THP-1 conditioned medium (500 ng/mL LPS treatment for 4 hr and 1 mM ATP treatment for 1.5 hr)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, inflammatory caspases are generally not involved in cell death but play roles in immune responses to microbial pathogens. Members such as caspase-1, -4, -5, and -12 activate proinflammatory cytokines including IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme and later found to be a mammalian homolog of the C. elegans cell death gene ced-3, capable of inducing apoptosis in fibroblasts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.