Thermo Fisher Scientific Human/Mouse/Rat BDNF, Animal-Free Recombinant Protein, PeproTech
Animal-Free 재조합 단백질로 Human, Mouse, Rat BDNF 연구용에 적합. E. coli 발현 시스템 사용, ≥98% 순도. TrkB Fc Chimera 결합 기능 검증. 신경세포 생존 및 분화 연구에 활용 가능.
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Applications
ELISA
- Tested Dilution: Assay-dependent
Functional Assay
- Tested Dilution: Assay-dependent
- Publications: 2
In vitro Assay
- Publications: 45
Miscellaneous PubMed
- Publications: 8
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human, Mouse, Rat |
| Published Species | Amphibian, Chicken, Human, Mouse, Non-human primate, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR |
| Molecular Weight | 27 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥98% (SDS-PAGE gel and HPLC analyses) |
| Endotoxin Concentration | <0.1 EU/µg |
| Activity | Ability to bind recombinant human TrkB Fc Chimera in functional ELISA |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer composed of two 120 amino acid subunits linked by strong non-covalent interactions.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, refer to the lot-specific Certificate of Analysis.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. It is synthesized as pre-proBDNF, then cleaved to proBDNF. Both pro- and mature BDNF are biologically active and secreted in synaptic vesicles.
BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on various neuron classes. Signaling primarily occurs through the TrkB receptor, but also involves p75-NTR.
BDNF promotes neuronal survival and differentiation and plays key roles in memory formation and synaptic regulation. Reduced expression of BDNF has been observed in Alzheimer’s and Huntington’s disease, and it may influence stress response and mood regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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