Thermo Fisher Scientific CYP27A1 Polyclonal Antibody
CYP27A1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 등 다양한 응용 가능. 인간 및 생쥐 반응성, 항원 친화 크로마토그래피로 정제됨. 콜레스테롤 대사 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 43–384 of Human CYP27A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547377 |
Product Specific Information
- Recommended positive controls: A431, H1299, HeLa, HepG2, mouse liver
- Predicted reactivity: Pig (80%), Rabbit (82%), Rhesus Monkey (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways. It initiates the acidic pathway by introducing a hydroxyl group at the 27 position of cholesterol, producing 27-hydroxycholesterol. In the classic pathway, it produces 3β-hydroxy-5-cholestenoic acid. CYP27A1 also contributes to vitamin D3 metabolism. It is expressed in multiple tissues, though its specific roles are not fully characterized. In macrophages, 27-hydroxycholesterol may help reduce inflammatory factors linked to cardiovascular disease.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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