Thermo Fisher Scientific COMT Polyclonal Antibody
COMT 단백질을 인식하는 Rabbit polyclonal antibody로 Western blot 및 IHC에 적합. 인간 및 설치류에 반응하며 높은 특이성과 재현성을 제공. 연구용으로 사용되며 장기 보관 시 -20°C에서 안정적 유지.
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Thermo Fisher Scientific COMT Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:3,000
- Immunohistochemistry (Paraffin) (IHC-P): 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 1–149 of Human COMT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.52 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2547375 |
Product Specific Information
- Recommended positive control: K562
- Predicted reactivity: Human (99%), Mouse (83%), Rat (81%), Dog (81%), Pig (85%), Rhesus Monkey (94%), Bovine (83%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines such as dopamine, epinephrine, and norepinephrine. This O-methylation is a major degradative pathway for catecholamine neurotransmitters. COMT also participates in the metabolism of catechol drugs used for hypertension, asthma, and Parkinson’s disease.
COMT exists in two forms: soluble (S-COMT) and membrane-bound (MB-COMT), differing in their N-termini. Multiple transcript variants arise from alternative translation initiation sites and promoters.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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