Thermo Fisher Scientific GRIK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GRIK1, validated for ICC/IF applications. Recognizes glutamate receptor 5 involved in neuronal signaling. Supplied as liquid form with 0.1 mg/mL concentration, affinity purified, and suitable for research use ...
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 400–449). Recombinant protein control fragment (Product #RP-109925) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS (pH 7.2) with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term; for long-term storage, store at -20°C (avoid freeze/thaw cycles) |
| Shipping conditions | Wet ice |
| RRID | AB_3091966 |
Product Specific Information
- Immunogen sequence:
TEKAAGEVSK HLYKVWKKIG IWNSNSGLNM TDSNKDKSSN ITDSLANRTL - Antigen sequence identity: Mouse 90%; Rat 90%
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiologic processes.
Grik1 (glutamate receptor 5) belongs to the kainate family of glutamate receptors, composed of four subunits functioning as ligand-activated ion channels.
Grik1 is expressed in GABAergic interneurons of the hippocampus and participates in forming kainate receptor subtypes with Grik2 and KA2.
Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological, and neurodegenerative diseases.
Multiple isoforms of Grik1 may exist and can undergo RNA editing within the second transmembrane domain, potentially altering ion flow properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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