Thermo Fisher Scientific GSTM3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Not specified
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500
• View publication

Product Specifications

Product Specific Information

Immunogen sequence:
TYDILDQNRI FDPKCLDEFP NLKAFMCRFE ALEKIAAYLQ SDQFCKMPIN N

Highest antigen sequence identity to the following orthologs:

• Mouse: 90%
• Rat: 86%

Target Information

Glutathione S-transferase M3 (brain), also known as GSTM3, is an enzyme encoded by the GSTM3 gene in humans. This enzyme belongs to the mu class of glutathione S-transferases, which function in detoxification of electrophilic compounds such as carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products through conjugation with glutathione.
The mu class genes are organized in a cluster on chromosome 1p13.3 and are highly polymorphic. These genetic variations can influence susceptibility to toxins and carcinogens, as well as drug efficacy and toxicity. Mutations in this gene have been associated with a slight increase in cancer risk due to environmental toxin exposure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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