Thermo Fisher Scientific TAB3 Polyclonal Antibody
Human TAB3 단백질을 인식하는 Rabbit Polyclonal Antibody로 NF-κB 신호전달 및 자가포식 연구에 적합. Western blot과 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며 4°C에서 보관.
- 카탈로그번호
- A302208Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TAB3 Polyclonal Antibody
Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 650 and 700 of Human TAK1 binding protein 3 (mitogen-activated protein kinase kinase kinase 7 interacting protein 3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TAB3 functions in the NF-κB signal transduction pathway. Together with TAB2, it forms a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with TNF or IL-1. TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-κB transcription factor.
TAB2 and TAB3 also interact with the autophagy mediator Beclin-1; upon induction of autophagy, they dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while their depletion triggers it, suggesting that these proteins act as a control point for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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