Thermo Fisher Scientific Vinculin Polyclonal Antibody
Thermo Fisher Scientific의 Vinculin Polyclonal Antibody는 인간, 마우스, 랫트 등 다양한 종에 반응하며 Western blot과 IHC(Paraffin)에 적합합니다. 액상 형태로 항원 친화 크로마토그래피로 정제되었으며, 세포 접착 및 골격 단백질 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Vinculin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.11 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2792422 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (98%), Rat (97%), Pig (99%), Chicken (93%), Bovine (99%).
- Positive Control: PC-12, Rat2, Jurkat, Raji, NCI-H929, Mouse muscle.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. A sequence of molecular interactions is involved in the transmembrane assembly of adhesion plaques. In this process, the beta subunit of integrin binds to talin, which binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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