Thermo Fisher Scientific FBXW7 Polyclonal Antibody
FBXW7 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 ELISA에 사용 가능하며, 인간 시료 반응성. 고순도 친화 크로마토그래피 정제 제품으로 안정적인 액상 형태 제공. 연구용으로만 사용.
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Thermo Fisher Scientific FBXW7 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Rabbit Polyclonal to F-box hCdc4 (69 kDa isoform) Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_558899 |
Product Specific Information
PA1-23468 detects F-box hCdc4 in human samples.
Target Information
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. These proteins form part of the SCF (SKP1–Cullin–F-box) ubiquitin ligase complex, functioning in phosphorylation-dependent ubiquitination.
F-box proteins are classified into three types:
- Fbws: Contain WD-40 domains
- Fbls: Contain leucine-rich repeats
- Fbxs: Contain other interaction modules or no recognizable motifs
FBXW7, also known as FBX30, belongs to the Fbws class and includes 7 tandem WD40 repeats. It binds directly to cyclin E and likely targets it for ubiquitin-mediated degradation. Mutations in this gene have been detected in ovarian and breast cancer cell lines, suggesting its involvement in cancer pathogenesis. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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