Thermo Fisher Scientific ACO1 Monoclonal Antibody (2C1)
ACO1 단백질을 인식하는 Thermo Fisher의 Mouse Monoclonal Antibody(2C1). Western blot, ELISA, IP에 적합하며 인간 시료에 반응. PBS 용액 형태로 제공되며 보존제 무첨가, -20°C에서 보관. 세포 내 철 항상성 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C1 |
| Immunogen | ACO1 (AAH18103, 780 a.a. ~ 889 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
RDWAAKGPFL LGIKAVLAES YERIHRSNLV GMGVIPLEYL PGENADALGL TGQERYTIII PENLKPQMKV QVKLDTGKTF QAVMRFDTDV ELTYFLNGGI LNYMIRKMAK
Target Information
Aconitase 1 (ACO1), also known as Iron Regulatory Element Binding Protein 1 (IREB1), is a cytosolic protein that binds to iron-responsive elements (IREs) and plays a central role in cellular iron homeostasis.
It also exhibits aconitase activity and is classified within the aconitase enzyme family.
IREs are stem-loop structures located in the 5′ UTR of ferritin mRNA and the 3′ UTR of transferrin receptor mRNA.
Binding of IREB1 to IREs regulates translation and stability of these mRNAs, maintaining iron balance in the cell.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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