Thermo Fisher Scientific PRAME nuclear receptor transcriptional regulator Monoclonal Antibody (PRAME/9188)
인간 PRAME 단백질을 인식하는 단클론 항체로, IHC(P)에서 1–2 µg/mL 농도로 사용 가능. 핵, 세포질, 골지체 등 다양한 세포 위치에서 발현 확인. 멜라노마 및 급성 백혈병 연구에 적합. Protein A/G 정제, 4°C 보관.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PRAME/9188 |
| Immunogen | Recombinant fragment (around aa100–250) of human PRAME protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human testis or melanoma
- Cellular Location: Nucleus, Chromosome, Cytoplasm, Golgi apparatus, Cell membrane
Target Information
This gene encodes an antigen predominantly expressed in human melanomas and recognized by cytolytic T lymphocytes. It is not expressed in normal tissues except testis. The expression pattern is similar to other cancer/testis (CT) antigens such as MAGE, BAGE, and GAGE, but unlike these, it is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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