Thermo Fisher Scientific Bedinvetmab Recombinant Canine Monoclonal Antibody

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Endotoxin level < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Bedinvetmab is a biosimilar that targets NGF (Nerve Growth Factor).
NGF influences the survival and differentiation of various neuronal and non-neuronal cells through specific high- and low-affinity receptors. Only the high-affinity receptor mediates signal transduction.
Cross-linking studies with 125I-NGF have shown that the high-affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF, while the low-affinity receptor forms an Mr 100,000 complex.
Full-length cDNA clones for both human and rat NGF receptor genes show greater than 90% homology.
NGF exhibits nerve growth–stimulating activity and regulates growth and differentiation of sympathetic and sensory neurons.
Mutations in the NGF gene are associated with hereditary sensory and autonomic neuropathy type 5 (HSAN5), and dysregulation of NGF expression is linked to allergic rhinitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.