Thermo Fisher Scientific Relfovetmab Recombinant Feline Monoclonal Antibody

Applications

• ELISA (Assay-dependent)

Product Specifications

Product Specific Information

• Endotoxin level < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Relfovetmab is a biosimilar that targets NGF.
Nerve growth factor (NGF) influences the survival and differentiation of various neuronal and nonneuronal cells. NGF binds to specific receptors on the cell surface, which exist as high and low affinity sites. Only the high affinity receptor is capable of signal transduction.
Cross-linking studies with ¹²⁵I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF, while the low affinity receptor forms an Mr 100,000 complex.
Full-length cDNA clones for human and rat NGF receptor genes show greater than 90% homology. NGF plays a key role in neuronal growth and differentiation, and its dysregulation is associated with conditions such as hereditary sensory and autonomic neuropathy type 5 (HSAN5) and allergic rhinitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.