Thermo Fisher Scientific Calmodulin Polyclonal Antibody
Rabbit polyclonal antibody recognizing Calmodulin in human, mouse, and rat. Validated for Western blot with high specificity. Supplied as liquid, purified by antigen affinity chromatography. Suitable for research on calcium signaling and protein regula...
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of Human Calmodulin (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735565 |
Product Specific Information
- Positive Control: Mouse brain, Rat brain
- Predicted Reactivity: Human (100%), Xenopus laevis (100%), Pig (100%), Chicken (100%), Chimpanzee (98%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Calmodulin mediates the control of numerous enzymes, ion channels, aquaporins, and other proteins by Ca²⁺. The calmodulin–Ca²⁺ complex stimulates several protein kinases and phosphatases. Together with CCP110 and centrin, it participates in regulating the centrosome cycle and cytokinesis.
Calmodulin is a small, highly conserved calcium-binding protein (17 kDa) found in all eukaryotic cells. It binds up to four calcium ions and acts as an intracellular receptor for calcium signals, undergoing conformational changes that increase affinity for target proteins.
It regulates energy metabolism, cell motility, exocytosis, cytoskeletal assembly, and intracellular cAMP and calcium modulation. Calmodulin contains 149 amino acids and four calcium-binding domains, functioning in growth, cell cycle, signal transduction, and neurotransmitter synthesis and release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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